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Document 2108
DOCN M94A2108
TI Behavioral patterns and HIV seroconversion among injecting drug users in
Rome, in the early 1990s.
DT 9412
AU Zaccarelli M; Gattari P; Rezza G; Spizzichino L; Portaleone A; Valenzi
C; Visco G; Gigli B; III Divisione Malattie Infettive, Ospedale L.
Spallanzani, Rome,; Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):38 (abstract no. 125C). Unique
Identifier : AIDSLINE ICA10/94370467
AB INTRODUCTION: HIV infection has been epidemic among injecting drug users
(IDUs) in Italy for over 10 years. More recently, an increasingly high
rate of new infections has been observed in the three largest Italian
cities, despite reports of empirical changes in drug taking practices.
This study is aimed at identifying risk factors currently associated
with HIV seroconversion among IDUs. METHODS: A brief standard interview
was conducted among initially HIV negative IDUs, who underwent at least
one subsequent HIV test between January 1992 and December 1993. RESULTS:
Overall, 333 IDUs were retested, among whom 13 seroconversions (3.9%)
were observed during the study period. Only 13.5% of participants
reported needle-sharing overall and 11.4% with their sexual IDU partner.
Moreover, in the past six months, 38.1% reported that they had sex with
an IDU partner, but only 10.2% with a known HIV positive partner; 8.9%
of males reported homosexuality. Variables significantly associated with
seroconversion were: history of injection < 3 years (RR = 3.2; 95% CI =
1.0-10.2), reported HIV positive partner (RR = 26.6; 95% CI = 7.6-92.4),
reported IDU partner (RR = 5.8; 95% CI = 1.6-21.4), reported
needle-sharing with IDU partner (RR = 5.3; 95% CI = 1.7-17.6), and
reported syringe-mediated drug sharing (RR = 3.9; 95% CI = 1.1-13.3).
Age < 21 years (RR = 3.4; 95% CI = 0.9-13.1) and reported needle-sharing
in the past six months (RR = 3.0; 95% CI = 0.9-10.3) were found to be
marginally associated. After multiple logistic regression analysis, only
reported HIV sexual partner in the past six months (OR = 35.3; 95% CI =
8.9-140.6) and age < 21 years (OR = 7.2; 95% CI = 1.3-39.6) were found
to be significantly associated with seroconversion. CONCLUSIONS:
Although the proportion of IDUs reporting needle-sharing still appears
to be high, prevention efforts should focus on reducing sexual
transmission of HIV, which, as our data indicate, is becoming
increasingly relevant among IDUs in Rome.
DE Adolescence Adult AIDS Serodiagnosis Female Human HIV
Seropositivity/*PSYCHOLOGY Male Needle Sharing Regression Analysis
Rome/EPIDEMIOLOGY Sex Behavior Substance Abuse,
Intravenous/COMPLICATIONS/*PSYCHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).